Although many deadlines have passed for 2019, two additional Big Ideas that currently do not have open funding opportunities could be a source of new solicitations in the future per a February 12 NSF Dear Colleague letter..
NSF INCLUDES: Transforming education and career pathways to help broaden participation in science and engineering. (https://www.nsf.gov/news/special_reports/big_ideas/includes.jsp)
Understanding the Rules of Life: Elucidating the sets of rules that predict an organism's observable characteristics, its phenotype. (https://www.nsf.gov/news/special_reports/big_ideas/life.jsp)
For more information on these funding opportunities, please contact the cognizant program officer listed on the specific web page.